While examining a patient's breasts, the nurse notes multiple, bilateral mobile lumps. To assess the patient further, what is the most appropriate question by the nurse?

A、a. “Do you have a high caffeine intake?”;

B、b. “When did you last have a mammogram?”;

C、c. “Is there a history of breast cancer in your mother or sisters?”;

D、d. “Do the size and tenderness of the lumps change with your menstrual cycle?”